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Drug Targets for Ebola, Dengue, and Zika Viruses Found in Lab Study

The method uses human cells in laboratory dishes to create a map of each point of contact between viral and human proteins ... Image by Elizabeth Di Lullo In the second paper, Krogan’s laboratory ...

SLU’s Adrian Di Bisceglie Named Fellow of the Academy of Science St. Louis

At SLU, Di Bisceglie led clinical trials and authored research that made significant contributions to the new viral hepatitis treatment options now available to patients. Of particular note is his ...

Creative Minds: Teaming Math and Science for an HIV Cure

While current treatments are able to reduce some patients’ HIV burden to very low or even undetectable levels, it is eradication of this viral reservoir that stands ... with different compounds, this ...

Viral fusion efficacy of specific H3N2 influenza virus reassortant combinations at single-particle level

Relative viral membrane HA density of matching pseudoparticles was ... The neuraminidase inhibitor N-Acetyl-2,3-dehydro-2-deoxyneuraminic acid (NADNA) (Sigma-Aldrich) was dissolved in DI water to 2 mg ...

Ebola vaccine R&D: Filling the knowledge gaps

1 Laboratorio di Microbiologia Molecolare e Biotecnologia (LA.M.M.B ... also triggered an undesirable “reactogenic” response—including the development of viral oligoarthritis in multiple joints within ...

What a Year It Was! A Look Back at Research Progress in 2017

All involved varying degrees of NIH support, and all drew great interest from readers ... But what’s more, a different gene therapy approach using a viral vector to deliver a normal copy of the SMN1 ...

Zika in Fetal Brain Tissue Responds to a Popular Antibiotic

Image by Elizabeth Di Lullo Working in the lab, UC San Francisco researchers have identified fetal brain ... in work funded by the National Institutes of Health (NIH) through the 2014 Brain Research ...

Serotype survey of AAV gene delivery via subconjunctival injection in mice

Inhibition of corneal neovascularization with endostatin delivered by adeno-associated viral (AAV) vector in a mouse corneal injury ... 2001;75:6884–93. Rocha EM, Di Pasquale G, Riveros PP, Quinn K, ...

Hepatitis C Treatment Reduces the Virus but Liver Damage Continues

Treating patients who have chronic hepatitis C and advanced liver disease with long-term pegylated interferon significantly decreased their liver enzymes, viral levels and liver ... the National ...

Hepatitis C Treatment Reduces the Virus but Serious Liver Problems May Progress

Patients with chronic hepatitis C and advanced liver disease who did not respond to previous standard therapy experienced significant decreases in their liver enzymes, viral levels ... National ...